Tesofensine

Description

High-Level Summary

Tesofensine is a centrally acting monoamine reuptake inhibitor that modulates the brain’s satiety and appetite regulation centers. Originally developed for neurodegenerative diseases, it was later repurposed for obesity research due to its potent effects on weight loss and caloric intake reduction. Tesofensine’s mechanism involves the inhibition of dopamine, serotonin, and norepinephrine reuptake, enhancing neurotransmitter signaling in appetite and reward pathways.

– Form: Lyophilized or powdered research compound
– Purity: ≥99%
– Origin: Manufactured and tested in the USA
– Certifications: Certificate of Analysis (COA) included with every order

Mechanism of Action (MOA)

Tesofensine works by:
– Inhibiting the presynaptic reuptake of dopamine, norepinephrine, and serotonin
– Enhancing satiety signaling in the hypothalamus
– Reducing appetite and food cravings via central nervous system activation
– Potentially increasing resting energy expenditure
– Influencing reward circuitry linked to feeding behavior

Research Applications

– Obesity and appetite suppression models
– Neurotransmitter signaling studies
– CNS-acting weight loss agents
– Reward pathway modulation
– Investigational therapies for binge eating or metabolic slowdown

Key Benefits for Research

– Highly potent central appetite suppressant
– Targets three major monoamine systems simultaneously
– Well-characterized pharmacokinetics in clinical and preclinical models
– Valuable for translational obesity and neuroendocrine studies

Certificate of Purity & Testing

Each vial is:
– Manufactured in a GMP-compliant U.S. facility
– Accompanied by a Certificate of Analysis (COA)
– Subjected to HPLC and mass spectrometry verification
– Shipped from within the United States for quality control

Formulation & Dosage Info

– Contents: 5mg of lyophilized Tesofensine or powdered compound
– Appearance: White to off-white powder
– Solubility: DMSO or ethanol for in vitro studies; consult research protocols
– Storage: Store at -20°C in a desiccated environment; protect from light
*For laboratory research use only. Not intended for human or veterinary use.*

Legal & Compliance Notices

– This product is sold for research purposes only
– Not for human consumption, injection, or diagnostic procedures
– Must be handled by qualified professionals in accordance with institutional and governmental safety guidelines