FOXO4-DRI

Description

High-Level Summary

FOXO4-DRI is a synthetic senolytic peptide designed to selectively induce apoptosis in senescent cells while sparing healthy cells. By disrupting the interaction between FOXO4 and p53, FOXO4-DRI allows the natural cell death pathway to proceed in damaged or senescent cells. This mechanism opens new doors in research related to age-associated disorders, tissue regeneration, and cellular longevity.

– Form: Lyophilized peptide
– Purity: >99%
– Origin: Manufactured and tested in the USA
– Documentation: Certificate of Analysis (COA) included

Mechanism of Action (MOA)

FOXO4-DRI works by blocking the FOXO4-p53 interaction in senescent cells. In normal cells, FOXO4 binds to p53 and prevents it from initiating apoptosis. In senescent cells, this leads to accumulation and inflammation. FOXO4-DRI disrupts this interaction, freeing p53 to trigger cell death and selectively clearing dysfunctional cells, reducing inflammatory burden and potentially improving tissue function.

Research Applications

– Senescence and aging research
– Studies on tissue regeneration and repair
– Inflammation and immune aging models
– Neurodegeneration and frailty studies
– Oncology and preclinical senolytic trials

Key Benefits for Research

– Promotes clearance of senescent cells
– Reduces chronic inflammation and SASP (senescence-associated secretory phenotype)
– Improves tissue health and regenerative potential
– Aids in studying anti-aging mechanisms at the cellular level

Certificate of Purity & Testing

Each vial is:
– Produced in a GMP-compliant U.S. facility
– Accompanied by a Certificate of Analysis (COA)
– Verified via HPLC and mass spectrometry
– Securely shipped with quality-control documentation

Formulation & Dosage Info

– Contents: 5mg FOXO4-DRI lyophilized peptide
– Appearance: White to off-white powder
– Solubility: Reconstitute with sterile bacteriostatic water
– Storage: Store at -20°C; refrigerate after reconstitution and use within 30 days
*For research use only. Not for human or veterinary consumption.*

Legal & Compliance Notices

– Intended for laboratory research only
– Not approved for human consumption or clinical use
– Buyer assumes all responsibility for legal research use