KPV (α-MSH fragment)

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KPV is a synthetic tripeptide derived from

\alpha

-MSH that is extensively studied for its potent anti-inflammatory and immunomodulatory effects without causing skin pigmentation, showing promise in research models for gastrointestinal, dermatological, and autoimmune diseases.

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Product Summary

High-Level Summary

KPV is a synthetic tripeptide fragment derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH). It is extensively studied for its potent anti-inflammatory and immunomodulatory effects without the pigment-inducing properties of full-length α-MSH. KPV has shown promise in gastrointestinal, dermatological, and autoimmune disease models, offering researchers a unique tool for exploring cytokine regulation, epithelial repair, and mucosal immune response.

– Form: Lyophilized peptide
– Purity: ≥99%
– Origin: Manufactured and tested in the USA
– Certifications: Certificate of Analysis (COA) included with every order

Mechanism of Action (MOA)

KPV exerts anti-inflammatory effects by:
– Inhibiting pro-inflammatory cytokines (e.g., TNF-α, IL-6, IL-1β)
– Blocking NF-κB signaling pathway
– Supporting epithelial barrier integrity and wound repair
– Modulating immune cell infiltration and oxidative stress
– Interacting with melanocortin receptors, especially MC1R

Research Applications

– Inflammatory bowel disease models (e.g., ulcerative colitis)
– Dermatological inflammation (e.g., eczema, psoriasis)
– Wound healing and tissue repair studies
– Gut-immune axis exploration
– Cytokine and oxidative stress modulation

Key Benefits for Research

– Non-pigmenting anti-inflammatory peptide
– High selectivity for pro-inflammatory signaling pathways
– Safe and well-tolerated in preclinical models
– Precise modulation of cytokine cascades

Certificate of Purity & Testing

Each vial is:
– Manufactured in a GMP-compliant U.S. facility
– Accompanied by a Certificate of Analysis (COA)
– Subjected to HPLC and mass spectrometry verification
– Shipped from within the United States for quality control

Formulation & Dosage Info

– Contents: 5mg, 10, 50 of lyophilized KPV peptide
– Appearance: White/off-white powder
– Solubility: Sterile bacteriostatic water or acetic acid recommended
– Storage: Store lyophilized vial at -20°C; reconstituted solution stable up to 30 days when refrigerated
*For laboratory research use only. Not intended for human or veterinary use.*

Legal & Compliance Notices

– This product is sold for research purposes only
– Not for human consumption, injection, or diagnostic procedures
– Must be handled by qualified professionals in accordance with institutional and governmental safety guidelines